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Bupropion Information
What is Bupropion?
Bupropion is the active drug found in the brand-name drugs Wellbutrin and Zyban. It was first approved by the FDA in 1985 for treating depression. Bupropion differs substantially from other antidepressants, particularly in the way it acts upon the neurotransmitters norepinephrine and dopamine. Over a decade later, it was discovered that Bupropion could be used as a smoking cessation aid. It gained FDA approval for helping people quit smoking in 1997. This led to a surge in popularity for the medicine and it became one of the most-prescribed antidepressants in the USA in 2007. Bupropion is now available in generic forms worldwide.
Bupropion Indications
Under the brand name of Wellbutrin, Bupropion is indicated for treating depression. Under the brand name of Zyban, Bupropion is indicated for aiding in smoking cessation. Bupropion may also be used for various other indications which are not FDA approved including sexual dysfunction, obesity, attention deficit hyperactive disorder, seasonal affective disorder, as well as other conditions.
How to take Bupropion
The dosage amount and frequency of Bupropion depends on many factors including your specific condition, the form of the drug being used, and how you respond to the medicine. Typically, treatment with Bupropion is initiated at low dosage levels and then is gradually increased as needed. Dosage should be reassessed by a doctor on a regular basis. The typical dosage of Bupropion for depression is 300 mg taken 3 times daily. The typical dosage of Bupropion for smoking cessation is 150 mg taken 2 times daily. Follow all your doctor's instructions about when to take the dosages. Usually, patients may take Bupropion without regards to meals. Always swallow the sustained-release tablets of Bupropion whole without crushing or chewing them.
Bupropion Side Effects
It is common for Bupropion to cause some adverse effects when treatment is first initiated. These effects are usually not serious and will go away as your body gets used to the medicine. You should inform your doctor in the event that any of these side effects are long lasting or become worse: feeling nauseous, lack of salivation, mild migraine, infrequent bowel movements, pain in joints, sore throat, blurry eyesight, unusual perspiration, vertigo, or unusual tastes in mouth. In the event that you have any of these uncommon to rare side effects while taking Bupropion, you should contact your doctor promptly: angina, loss of conscious, changes to heart rate/beats, changes to hearing, severe migraine, changes to weight, tremors, unusual moods/behaviors, muscular pains, or changes to urination. Get medical attention right away if you have a seizure while taking Bupropion.
Warnings about Bupropion
As with other antidepressant drugs, there are reports that Bupropion may worsen or cause mood disorders. Patients may also experience an increased likelihood of committing suicide as a result of taking antidepressants like Bupropion. Regardless of whether you are taking Bupropion for a mood disorder or to help quit smoking, talk to your doctor about the risks of taking Bupropion. If you have any unusual moods during treatment (such as becoming depressed, angry, suicidal, or anxious) or your mood disorder worsens, immediately contact your doctor.
Bupropion Contraindications
Do not take Bupropion without first informing your health care provider about your complete health history. Certain health risk factors may make it unsafe for you to use this drug. The following conditions may be contraindicated for Bupropion: conditions causing seizures, bulimia, anorexia, drug withdrawal, current/past drug abuse, tumors, diabetes, brain damage, cardiovascular problems, hepatic disease, certain psychiatric problems, or allergies. Note that your health care provider may still decide to prescribe v Bupropion to you but you may need to follow special dosing or monitoring instructions.
Bupropion during Pregnancy and Breastfeeding
Bupropion is FDA pregnancy category C. This means that the exact risks of taking Bupropion during pregnancy are currently not known. However, there is evidence that taking Bupropion, especially in the last trimester of pregnancy, can cause harm to an unborn child including problems after birth. Do not take Bupropion if you are pregnant without first consulting your doctor. If you become pregnant during treatment, you should immediately tell your doctor. Bupropion should not be used while breastfeeding as it can be passed to a nursing child and cause harm.
Generic Forms of Bupropion
The FDA did not approve generic Bupropion for many years after the drug was introduced. Then, when Bupropion was first approved in generic form, there were many reports of patients experiencing recurrences of their condition after they switched to the generic form. There were many complaints that the quality of generic Bupropion did not meet the brand-name version. Thus, drug regulation laws were established which require all generic forms of Bupropion contain the same quality of active ingredients, methods of administering, and are labeled the same as the brand-name version. Since these regulations were put into place, many forms of generic Bupropion have been approved by the FDA and are available worldwide. Patients should experience no difference in treatment of their condition with generic Bupropion vs. the brand name forms of Wellbutrin or Zyban.